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$RIGL Let's not forget the NIH's wonderful research into NETosis, fostamatinib and C19.tomengine, published July 28, 2021
NIH doctor discussing NETosis: "Some preliminary data suggests using a tyrosine kinase inhibitor (fostamatinib) we can fully reverse these phenotypes which is something that has us excited to study these implications moving forward."
Lead investigator: Just out in JID, @dr_mjramos and I along with others show that R406 (fostamatinib) can inhibit NETs when neutrophils are stimulated with COVID-19 plasma.
NIH lead study publication: This is the first report to identify that R406, a potent SYK inhibitor and the metabolically active component of fostamatinib, inhibits NETosis among healthy donor neutrophils stimulated with COVID-19 patient plasma.
This, along with the inhibition of the cytokine storm and other hyper-inflammatory processes put us miles ahead of any other therapeutic for C19 and is why we'll get a EUA off an n=59.